Central & South America Cruise Dates - 2026 & 2027
Uncover the rich culture, vibrant cities, and dramatic landscapes of Central and South America on a cruise adventure like no other. Plan your unforgettable Central & South America 2026 & 2027 voyages now — book early for the best cabins and exclusive early bird offers. Looking for inspiration? See our Central & South America cruise destination page.
Explore our wide selection of Central & South America cruises below. Use the filters to find the perfect itinerary that matches your travel dates and preferences.
South America
Panama Canal
Galapagos
We found
421 cruises
1 / 19
Duration
1 night
Date
1 Apr. 2027
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 2 stops
- Arrival - Rio de Janeiro, Brazil
1 / 39
Duration
1 night
Date
3 Apr. 2027
Ship
MSC Virtuosa
- Departure - Santos (São Paulo), Brazil
- 2 stops
- Arrival - Rio de Janeiro, Brazil
1 / 39
Duration
1 night
Date
1 Dez. 2026
Ship
MSC Virtuosa
- Departure - Rio de Janeiro, Brazil
- 2 stops
- Arrival - Santos (São Paulo), Brazil
1 / 19
Duration
1 night
Date
14 März 2027
Ship
MSC Musica
- Departure - Itajai, Brazil
- 2 stops
- Arrival - Santos (São Paulo), Brazil
1 / 19
Duration
2 nights
Date
20 Dez. 2026
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 3 stops
- Arrival - Rio de Janeiro, Brazil
1 / 19
Duration
3 nights
Date
8 Apr. 2027
Ship
Costa Serena
- Departure - Rio de Janeiro, Brazil
- 2 stops
- Arrival - Recife, Brazil
1 / 19
Duration
1 night
Date
13 März 2027
Ship
MSC Musica
- Departure - Paranaguá, Brazil
- 2 stops
- Arrival - Itajai, Brazil
1 / 19
Duration
2 nights
Date
13 März 2027
Ship
MSC Musica
- Departure - Paranaguá, Brazil
- 3 stops
- Arrival - Santos (São Paulo), Brazil
1 / 26
Duration
3 nights
Date
20 Nov. 2026
Ship
Costa Diadema
- Departure - Salvador de Bahia, Brazil
- 3 stops
- Arrival - Santos (São Paulo), Brazil
1 / 19
Discount
Duration
3 nights
Date
23 Nov. 2026
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 3 stops
- Arrival - Santos (São Paulo), Brazil
Show all departures (3)
1 / 19
Discount
Duration
3 nights
Date
30 Nov. 2026
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 3 stops
- Arrival - Santos (São Paulo), Brazil
1 / 19
Discount
Duration
3 nights
Date
3 Dez. 2026
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 3 stops
- Arrival - Santos (São Paulo), Brazil
Show all departures (3)
1 / 19
Discount
Duration
4 nights
Date
9 März 2027
Ship
MSC Musica
- Departure - Rio de Janeiro, Brazil
- 4 stops
- Arrival - Paranaguá, Brazil
1 / 19
Discount
Duration
3 nights
Date
24 Nov. 2027
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 3 stops
- Arrival - Santos (São Paulo), Brazil
Show all departures (2)
1 / 19
Discount
Duration
3 nights
Date
30 Nov. 2027
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 3 stops
- Arrival - Santos (São Paulo), Brazil
Show all departures (4)
1 / 30
Discount
Duration
3 nights
Date
30 März 2028
Ship
MSC Meraviglia
- Departure - Santos (São Paulo), Brazil
- 3 stops
- Arrival - Santos (São Paulo), Brazil
Show all departures (5)
1 / 19
Discount
Duration
4 nights
Date
9 Dez. 2027
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 4 stops
- Arrival - Santos (São Paulo), Brazil
1 / 19
Discount
Duration
4 nights
Date
16 Dez. 2027
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 4 stops
- Arrival - Santos (São Paulo), Brazil
1 / 39
Discount
Duration
4 nights
Date
3 Apr. 2027
Ship
MSC Virtuosa
- Departure - Santos (São Paulo), Brazil
- 4 stops
- Arrival - Salvador de Bahia, Brazil
1 / 19
Discount
Duration
4 nights
Date
16 Nov. 2026
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 4 stops
- Arrival - Santos (São Paulo), Brazil
1 / 19
Discount
Duration
4 nights
Date
26 Nov. 2026
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 4 stops
- Arrival - Santos (São Paulo), Brazil
Show all departures (2)
1 / 19
Discount
Duration
4 nights
Date
13 Dez. 2026
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 4 stops
- Arrival - Santos (São Paulo), Brazil
Show all departures (2)
1 / 19
Discount
Duration
4 nights
Date
15 März 2027
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 4 stops
- Arrival - Santos (São Paulo), Brazil
1 / 39
Discount
Duration
3 nights
Date
31 März 2027
Ship
MSC Virtuosa
- Departure - Maceió, Brazil
- 2 stops
- Arrival - Santos (São Paulo), Brazil
Show all departures (2)
1 / 30
Discount
Duration
4 nights
Date
2 Apr. 2028
Ship
MSC Meraviglia
- Departure - Santos (São Paulo), Brazil
- 4 stops
- Arrival - Santos (São Paulo), Brazil
Show all departures (2)
1 / 39
Discount
Duration
3 nights
Date
5 Dez. 2026
Ship
MSC Virtuosa
- Departure - Santos (São Paulo), Brazil
- 3 stops
- Arrival - Salvador de Bahia, Brazil
1 / 26
Duration
4 nights
Date
19 Nov. 2026
Ship
Costa Diadema
- Departure - Maceió, Brazil
- 4 stops
- Arrival - Santos (São Paulo), Brazil
1 / 39
Discount
Duration
3 nights
Date
2 Dez. 2026
Ship
MSC Virtuosa
- Departure - Santos (São Paulo), Brazil
- 3 stops
- Arrival - Santos (São Paulo), Brazil
1 / 33
Discount
Duration
3 nights
Date
2 Dez. 2026
Ship
MSC Seaview
- Departure - Santos (São Paulo), Brazil
- 3 stops
- Arrival - Santos (São Paulo), Brazil
1 / 26
Duration
6 nights
Date
4 Apr. 2027
Ship
Costa Diadema
- Departure - Santos (São Paulo), Brazil
- 4 stops
- Arrival - Fortaleza, Brazil
1 / 30
Discount
Duration
4 nights
Date
26 März 2028
Ship
MSC Meraviglia
- Departure - Santos (São Paulo), Brazil
- 4 stops
- Arrival - Santos (São Paulo), Brazil
1 / 39
Discount
Duration
4 nights
Date
30 März 2027
Ship
MSC Virtuosa
- Departure - Salvador de Bahia, Brazil
- 3 stops
- Arrival - Santos (São Paulo), Brazil
1 / 33
Discount
Duration
3 nights
Date
29 Nov. 2026
Ship
MSC Seaview
- Departure - Santos (São Paulo), Brazil
- 3 stops
- Arrival - Santos (São Paulo), Brazil
1 / 39
8 % off
Duration
6 nights
Date
3 Apr. 2027
Ship
MSC Virtuosa
- Departure - Santos (São Paulo), Brazil
- 5 stops
- Arrival - Maceió, Brazil
1 / 39
Discount
Duration
4 nights
Date
5 Dez. 2026
Ship
MSC Virtuosa
- Departure - Santos (São Paulo), Brazil
- 4 stops
- Arrival - Maceió, Brazil
Show all departures (2)
1 / 39
8 % off
Duration
7 nights
Date
15 Dez. 2026
Ship
MSC Virtuosa
- Departure - Salvador de Bahia, Brazil
- 5 stops
- Arrival - Salvador de Bahia, Brazil
Show all departures (15)
1 / 19
8 % off
Duration
7 nights
Date
20 Dez. 2026
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 7 stops
- Arrival - Itajai, Brazil
1 / 19
8 % off
Duration
7 nights
Date
27 Feb. 2027
Ship
MSC Musica
- Departure - Paranaguá, Brazil
- 7 stops
- Arrival - Paranaguá, Brazil
Show all departures (7)
1 / 19
8 % off
Duration
5 nights
Date
9 März 2027
Ship
MSC Musica
- Departure - Rio de Janeiro, Brazil
- 5 stops
- Arrival - Itajai, Brazil
1 / 19
8 % off
Duration
7 nights
Date
20 Feb. 2027
Ship
MSC Musica
- Departure - Paranaguá, Brazil
- 7 stops
- Arrival - Paranaguá, Brazil
1 / 19
8 % off
Duration
7 nights
Date
23 Feb. 2027
Ship
MSC Musica
- Departure - Rio de Janeiro, Brazil
- 7 stops
- Arrival - Rio de Janeiro, Brazil
Show all departures (7)
1 / 19
8 % off
Duration
7 nights
Date
14 Feb. 2027
Ship
MSC Musica
- Departure - Itajai, Brazil
- 7 stops
- Arrival - Itajai, Brazil
Show all departures (5)
1 / 19
8 % off
Duration
7 nights
Date
16 Feb. 2027
Ship
MSC Musica
- Departure - Rio de Janeiro, Brazil
- 7 stops
- Arrival - Rio de Janeiro, Brazil
1 / 19
8 % off
Duration
7 nights
Date
12 Feb. 2028
Ship
MSC Musica
- Departure - Paranaguá, Brazil
- 7 stops
- Arrival - Paranaguá, Brazil
Show all departures (8)
1 / 19
8 % off
Duration
7 nights
Date
13 Feb. 2028
Ship
MSC Musica
- Departure - Itajai, Brazil
- 7 stops
- Arrival - Itajai, Brazil
Show all departures (8)
1 / 19
8 % off
Duration
7 nights
Date
15 Feb. 2028
Ship
MSC Musica
- Departure - Rio de Janeiro, Brazil
- 7 stops
- Arrival - Rio de Janeiro, Brazil
Show all departures (8)
1 / 19
8 % off
Duration
7 nights
Date
21 Feb. 2027
Ship
MSC Musica
- Departure - Itajai, Brazil
- 7 stops
- Arrival - Itajai, Brazil
Show all departures (3)
1 / 29
Discount
Duration
3 nights
Date
3 Dez. 2026
Ship
MSC Splendida
- Departure - Buenos Aires, Argentina
- 2 stops
- Arrival - Rio de Janeiro, Brazil
1 / 19
8 % off
Duration
6 nights
Date
2 Jan. 2028
Ship
MSC Musica
- Departure - Paranaguá, Brazil
- 6 stops
- Arrival - Paranaguá, Brazil
1 / 19
8 % off
Duration
6 nights
Date
3 Jan. 2028
Ship
MSC Musica
- Departure - Itajai, Brazil
- 6 stops
- Arrival - Itajai, Brazil
1 / 19
8 % off
Duration
6 nights
Date
5 Jan. 2028
Ship
MSC Musica
- Departure - Rio de Janeiro, Brazil
- 6 stops
- Arrival - Rio de Janeiro, Brazil
1 / 19
8 % off
Duration
7 nights
Date
16 Jan. 2027
Ship
MSC Musica
- Departure - Paranaguá, Brazil
- 7 stops
- Arrival - Paranaguá, Brazil
1 / 19
8 % off
Duration
7 nights
Date
23 Jan. 2027
Ship
MSC Musica
- Departure - Paranaguá, Brazil
- 7 stops
- Arrival - Paranaguá, Brazil
1 / 19
8 % off
Duration
7 nights
Date
24 Jan. 2027
Ship
MSC Musica
- Departure - Itajai, Brazil
- 7 stops
- Arrival - Itajai, Brazil
1 / 19
8 % off
Duration
7 nights
Date
26 Jan. 2027
Ship
MSC Musica
- Departure - Rio de Janeiro, Brazil
- 7 stops
- Arrival - Rio de Janeiro, Brazil
Show all departures (2)
1 / 33
8 % off
Duration
7 nights
Date
31 Jan. 2027
Ship
MSC Seaview
- Departure - Santos (São Paulo), Brazil
- 5 stops
- Arrival - Santos (São Paulo), Brazil
Show all departures (9)
1 / 19
8 % off
Duration
6 nights
Date
9 März 2027
Ship
MSC Musica
- Departure - Rio de Janeiro, Brazil
- 6 stops
- Arrival - Santos (São Paulo), Brazil
1 / 33
8 % off
Duration
7 nights
Date
14 Dez. 2026
Ship
MSC Seaview
- Departure - Camboriu, Brazil
- 5 stops
- Arrival - Camboriu, Brazil
Show all departures (8)
1 / 39
8 % off
Duration
7 nights
Date
4 Dez. 2027
Ship
MSC Virtuosa
- Departure - Santos (São Paulo), Brazil
- 5 stops
- Arrival - Santos (São Paulo), Brazil
Show all departures (13)
1 / 33
8 % off
Duration
6 nights
Date
1 März 2027
Ship
MSC Seaview
- Departure - Camboriu, Brazil
- 4 stops
- Arrival - Santos (São Paulo), Brazil
1 / 30
8 % off
Duration
7 nights
Date
13 Feb. 2028
Ship
MSC Meraviglia
- Departure - Santos (São Paulo), Brazil
- 5 stops
- Arrival - Santos (São Paulo), Brazil
Show all departures (12)
1 / 30
8 % off
Duration
7 nights
Date
12 März 2028
Ship
MSC Meraviglia
- Departure - Santos (São Paulo), Brazil
- 5 stops
- Arrival - Santos (São Paulo), Brazil
Show all departures (2)
1 / 39
8 % off
Duration
6 nights
Date
2 Jan. 2028
Ship
MSC Virtuosa
- Departure - Santos (São Paulo), Brazil
- 5 stops
- Arrival - Santos (São Paulo), Brazil
1 / 30
8 % off
Duration
7 nights
Date
29 Nov. 2027
Ship
MSC Meraviglia
- Departure - Camboriu, Brazil
- 5 stops
- Arrival - Camboriu, Brazil
Show all departures (3)
1 / 30
8 % off
Duration
7 nights
Date
2 Dez. 2027
Ship
MSC Meraviglia
- Departure - Buenos Aires, Argentina
- 5 stops
- Arrival - Buenos Aires, Argentina
Show all departures (3)
1 / 39
8 % off
Duration
7 nights
Date
7 Dez. 2027
Ship
MSC Virtuosa
- Departure - Salvador de Bahia, Brazil
- 5 stops
- Arrival - Salvador de Bahia, Brazil
Show all departures (2)
1 / 39
8 % off
Duration
7 nights
Date
8 Dez. 2027
Ship
MSC Virtuosa
- Departure - Maceió, Brazil
- 5 stops
- Arrival - Maceió, Brazil
Show all departures (2)
1 / 19
5 % off
Duration
8 nights
Date
8 März 2027
Ship
Costa Serena
- Departure - Buenos Aires, Argentina
- 6 stops
- Arrival - Buenos Aires, Argentina
1 / 30
8 % off
Duration
6 nights
Date
3 Jan. 2028
Ship
MSC Meraviglia
- Departure - Santos (São Paulo), Brazil
- 4 stops
- Arrival - Santos (São Paulo), Brazil
1 / 19
8 % off
Duration
6 nights
Date
23 Dez. 2027
Ship
MSC Musica
- Departure - Rio de Janeiro, Brazil
- 6 stops
- Arrival - Rio de Janeiro, Brazil
1 / 39
8 % off
Duration
7 nights
Date
9 Feb. 2028
Ship
MSC Virtuosa
- Departure - Maceió, Brazil
- 5 stops
- Arrival - Maceió, Brazil
Show all departures (10)
1 / 30
8 % off
Duration
7 nights
Date
10 Feb. 2028
Ship
MSC Meraviglia
- Departure - Buenos Aires, Argentina
- 5 stops
- Arrival - Buenos Aires, Argentina
Show all departures (9)
1 / 30
8 % off
Duration
7 nights
Date
14 Feb. 2028
Ship
MSC Meraviglia
- Departure - Camboriu, Brazil
- 5 stops
- Arrival - Camboriu, Brazil
Show all departures (8)
1 / 39
8 % off
Duration
7 nights
Date
15 Feb. 2028
Ship
MSC Virtuosa
- Departure - Salvador de Bahia, Brazil
- 5 stops
- Arrival - Salvador de Bahia, Brazil
Show all departures (10)
1 / 30
8 % off
Duration
7 nights
Date
9 März 2028
Ship
MSC Meraviglia
- Departure - Buenos Aires, Argentina
- 5 stops
- Arrival - Buenos Aires, Argentina
Show all departures (2)
1 / 30
8 % off
Duration
7 nights
Date
13 März 2028
Ship
MSC Meraviglia
- Departure - Camboriu, Brazil
- 5 stops
- Arrival - Camboriu, Brazil
Show all departures (2)
1 / 29
8 % off
Duration
8 nights
Date
5 Dez. 2027
Ship
MSC Splendida
- Departure - Buenos Aires, Argentina
- 6 stops
- Arrival - Buenos Aires, Argentina
Show all departures (7)
1 / 29
8 % off
Duration
8 nights
Date
8 Dez. 2027
Ship
MSC Splendida
- Departure - Rio de Janeiro, Brazil
- 6 stops
- Arrival - Rio de Janeiro, Brazil
Show all departures (3)
1 / 39
8 % off
Duration
6 nights
Date
5 Jan. 2028
Ship
MSC Virtuosa
- Departure - Salvador de Bahia, Brazil
- 5 stops
- Arrival - Salvador de Bahia, Brazil
1 / 29
8 % off
Duration
8 nights
Date
19 März 2028
Ship
MSC Splendida
- Departure - Rio de Janeiro, Brazil
- 6 stops
- Arrival - Rio de Janeiro, Brazil
Show all departures (3)
1 / 39
8 % off
Duration
7 nights
Date
12 Dez. 2026
Ship
MSC Virtuosa
- Departure - Santos (São Paulo), Brazil
- 5 stops
- Arrival - Santos (São Paulo), Brazil
Show all departures (16)
1 / 33
8 % off
Duration
7 nights
Date
20 Dez. 2026
Ship
MSC Seaview
- Departure - Santos (São Paulo), Brazil
- 5 stops
- Arrival - Santos (São Paulo), Brazil
Show all departures (2)
1 / 33
8 % off
Duration
7 nights
Date
21 Dez. 2026
Ship
MSC Seaview
- Departure - Camboriu, Brazil
- 5 stops
- Arrival - Camboriu, Brazil
Show all departures (2)
1 / 33
8 % off
Duration
7 nights
Date
10 Jan. 2027
Ship
MSC Seaview
- Departure - Santos (São Paulo), Brazil
- 5 stops
- Arrival - Santos (São Paulo), Brazil
1 / 33
8 % off
Duration
7 nights
Date
11 Jan. 2027
Ship
MSC Seaview
- Departure - Camboriu, Brazil
- 5 stops
- Arrival - Camboriu, Brazil
1 / 29
8 % off
Duration
8 nights
Date
8 März 2028
Ship
MSC Splendida
- Departure - Buenos Aires, Argentina
- 6 stops
- Arrival - Buenos Aires, Argentina
1 / 29
8 % off
Duration
8 nights
Date
11 März 2028
Ship
MSC Splendida
- Departure - Rio de Janeiro, Brazil
- 6 stops
- Arrival - Rio de Janeiro, Brazil
1 / 29
8 % off
Duration
8 nights
Date
27 März 2028
Ship
MSC Splendida
- Departure - Rio de Janeiro, Brazil
- 6 stops
- Arrival - Rio de Janeiro, Brazil
1 / 30
8 % off
Duration
6 nights
Date
4 Jan. 2028
Ship
MSC Meraviglia
- Departure - Camboriu, Brazil
- 4 stops
- Arrival - Camboriu, Brazil
1 / 29
8 % off
Duration
8 nights
Date
6 Dez. 2026
Ship
MSC Splendida
- Departure - Rio de Janeiro, Brazil
- 6 stops
- Arrival - Rio de Janeiro, Brazil
Show all departures (6)
1 / 39
8 % off
Duration
7 nights
Date
9 Dez. 2026
Ship
MSC Virtuosa
- Departure - Maceió, Brazil
- 5 stops
- Arrival - Maceió, Brazil
Show all departures (14)
1 / 19
5 % off
Duration
9 nights
Date
27 Feb. 2027
Ship
Costa Serena
- Departure - Buenos Aires, Argentina
- 7 stops
- Arrival - Buenos Aires, Argentina
1 / 33
8 % off
Duration
8 nights
Date
5 Dez. 2026
Ship
MSC Seaview
- Departure - Santos (São Paulo), Brazil
- 6 stops
- Arrival - Santos (São Paulo), Brazil
1 / 33
8 % off
Duration
8 nights
Date
6 Dez. 2026
Ship
MSC Seaview
- Departure - Camboriu, Brazil
- 6 stops
- Arrival - Camboriu, Brazil
1 / 19
5 % off
Duration
9 nights
Date
18 Feb. 2027
Ship
Costa Serena
- Departure - Buenos Aires, Argentina
- 7 stops
- Arrival - Buenos Aires, Argentina
1 / 39
8 % off
Duration
8 nights
Date
21 März 2028
Ship
MSC Virtuosa
- Departure - Salvador de Bahia, Brazil
- 6 stops
- Arrival - Salvador de Bahia, Brazil
1 / 33
8 % off
Duration
5 nights
Date
5 Dez. 2026
Ship
MSC Seaview
- Departure - Santos (São Paulo), Brazil
- 5 stops
- Arrival - Buenos Aires, Argentina
1 / 19
8 % off
Duration
7 nights
Date
20 Dez. 2027
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 7 stops
- Arrival - Itajai, Brazil
1 / 14
Discount
Duration
16 nights
Date
12 Dez. 2026
Ship
Island Princess
- Departure - Fort Lauderdale, Florida
- 9 stops
- Arrival - Los Angeles, USA
1 / 19
5 % off
Duration
8 nights
Date
31 Jan. 2027
Ship
Costa Serena
- Departure - Buenos Aires, Argentina
- 6 stops
- Arrival - Buenos Aires, Argentina
100 of 421 pcs