Central & South America Cruise Dates - 2026 & 2027
Uncover the rich culture, vibrant cities, and dramatic landscapes of Central and South America on a cruise adventure like no other. Plan your unforgettable Central & South America 2026 & 2027 voyages now — book early for the best cabins and exclusive early bird offers. Looking for inspiration? See our Central & South America cruise destination page.
Explore our wide selection of Central & South America cruises below. Use the filters to find the perfect itinerary that matches your travel dates and preferences.
South America
Panama Canal
Galapagos
We found
416 cruises
1 / 19
Duration
1 night
Date
1 Apr 2027
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 2 stops
- Arrival - Rio de Janeiro, Brazil
1 / 39
Duration
1 night
Date
3 Apr 2027
Ship
MSC Virtuosa
- Departure - Santos (São Paulo), Brazil
- 2 stops
- Arrival - Rio de Janeiro, Brazil
1 / 39
Duration
1 night
Date
1 Dec 2026
Ship
MSC Virtuosa
- Departure - Rio de Janeiro, Brazil
- 2 stops
- Arrival - Santos (São Paulo), Brazil
1 / 19
Duration
1 night
Date
14 Mar 2027
Ship
MSC Musica
- Departure - Itajai, Brazil
- 2 stops
- Arrival - Santos (São Paulo), Brazil
1 / 19
Duration
2 nights
Date
20 Dec 2026
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 3 stops
- Arrival - Rio de Janeiro, Brazil
1 / 19
Duration
3 nights
Date
8 Apr 2027
Ship
Costa Serena
- Departure - Rio de Janeiro, Brazil
- 2 stops
- Arrival - Recife, Brazil
1 / 19
Duration
1 night
Date
13 Mar 2027
Ship
MSC Musica
- Departure - Paranaguá, Brazil
- 2 stops
- Arrival - Itajai, Brazil
1 / 19
Duration
2 nights
Date
13 Mar 2027
Ship
MSC Musica
- Departure - Paranaguá, Brazil
- 3 stops
- Arrival - Santos (São Paulo), Brazil
1 / 26
Duration
3 nights
Date
20 Nov 2026
Ship
Costa Diadema
- Departure - Salvador de Bahia, Brazil
- 3 stops
- Arrival - Santos (São Paulo), Brazil
1 / 19
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Duration
3 nights
Date
23 Nov 2026
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 3 stops
- Arrival - Santos (São Paulo), Brazil
Show all departures (3)
1 / 19
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Duration
3 nights
Date
30 Nov 2026
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 3 stops
- Arrival - Santos (São Paulo), Brazil
1 / 19
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Duration
3 nights
Date
3 Dec 2026
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 3 stops
- Arrival - Santos (São Paulo), Brazil
Show all departures (3)
1 / 19
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Duration
4 nights
Date
9 Mar 2027
Ship
MSC Musica
- Departure - Rio de Janeiro, Brazil
- 4 stops
- Arrival - Paranaguá, Brazil
1 / 19
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Duration
3 nights
Date
24 Nov 2027
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 3 stops
- Arrival - Santos (São Paulo), Brazil
Show all departures (2)
1 / 19
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Duration
3 nights
Date
30 Nov 2027
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 3 stops
- Arrival - Santos (São Paulo), Brazil
Show all departures (4)
1 / 30
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Duration
3 nights
Date
30 Mar 2028
Ship
MSC Meraviglia
- Departure - Santos (São Paulo), Brazil
- 3 stops
- Arrival - Santos (São Paulo), Brazil
Show all departures (5)
1 / 19
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Duration
4 nights
Date
9 Dec 2027
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 4 stops
- Arrival - Santos (São Paulo), Brazil
1 / 19
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Duration
4 nights
Date
16 Dec 2027
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 4 stops
- Arrival - Santos (São Paulo), Brazil
1 / 39
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Duration
4 nights
Date
3 Apr 2027
Ship
MSC Virtuosa
- Departure - Santos (São Paulo), Brazil
- 4 stops
- Arrival - Salvador de Bahia, Brazil
1 / 19
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Duration
4 nights
Date
16 Nov 2026
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 4 stops
- Arrival - Santos (São Paulo), Brazil
1 / 19
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Duration
4 nights
Date
26 Nov 2026
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 4 stops
- Arrival - Santos (São Paulo), Brazil
Show all departures (2)
1 / 19
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Duration
4 nights
Date
13 Dec 2026
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 4 stops
- Arrival - Santos (São Paulo), Brazil
Show all departures (2)
1 / 19
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Duration
4 nights
Date
15 Mar 2027
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 4 stops
- Arrival - Santos (São Paulo), Brazil
1 / 39
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Duration
3 nights
Date
31 Mar 2027
Ship
MSC Virtuosa
- Departure - Maceió, Brazil
- 2 stops
- Arrival - Santos (São Paulo), Brazil
Show all departures (2)
1 / 30
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Duration
4 nights
Date
2 Apr 2028
Ship
MSC Meraviglia
- Departure - Santos (São Paulo), Brazil
- 4 stops
- Arrival - Santos (São Paulo), Brazil
Show all departures (2)
1 / 39
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Duration
3 nights
Date
5 Dec 2026
Ship
MSC Virtuosa
- Departure - Santos (São Paulo), Brazil
- 3 stops
- Arrival - Salvador de Bahia, Brazil
1 / 26
Duration
4 nights
Date
19 Nov 2026
Ship
Costa Diadema
- Departure - Maceió, Brazil
- 4 stops
- Arrival - Santos (São Paulo), Brazil
1 / 39
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Duration
3 nights
Date
2 Dec 2026
Ship
MSC Virtuosa
- Departure - Santos (São Paulo), Brazil
- 3 stops
- Arrival - Santos (São Paulo), Brazil
1 / 33
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Duration
3 nights
Date
2 Dec 2026
Ship
MSC Seaview
- Departure - Santos (São Paulo), Brazil
- 3 stops
- Arrival - Santos (São Paulo), Brazil
1 / 26
Duration
6 nights
Date
4 Apr 2027
Ship
Costa Diadema
- Departure - Santos (São Paulo), Brazil
- 4 stops
- Arrival - Fortaleza, Brazil
1 / 30
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Duration
4 nights
Date
26 Mar 2028
Ship
MSC Meraviglia
- Departure - Santos (São Paulo), Brazil
- 4 stops
- Arrival - Santos (São Paulo), Brazil
1 / 39
Discount
Duration
4 nights
Date
30 Mar 2027
Ship
MSC Virtuosa
- Departure - Salvador de Bahia, Brazil
- 3 stops
- Arrival - Santos (São Paulo), Brazil
1 / 33
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Duration
3 nights
Date
29 Nov 2026
Ship
MSC Seaview
- Departure - Santos (São Paulo), Brazil
- 3 stops
- Arrival - Santos (São Paulo), Brazil
1 / 39
8 % off
Duration
6 nights
Date
3 Apr 2027
Ship
MSC Virtuosa
- Departure - Santos (São Paulo), Brazil
- 5 stops
- Arrival - Maceió, Brazil
1 / 39
Discount
Duration
4 nights
Date
5 Dec 2026
Ship
MSC Virtuosa
- Departure - Santos (São Paulo), Brazil
- 4 stops
- Arrival - Maceió, Brazil
Show all departures (2)
1 / 39
8 % off
Duration
7 nights
Date
15 Dec 2026
Ship
MSC Virtuosa
- Departure - Salvador de Bahia, Brazil
- 5 stops
- Arrival - Salvador de Bahia, Brazil
Show all departures (15)
1 / 19
8 % off
Duration
7 nights
Date
20 Dec 2026
Ship
MSC Musica
- Departure - Santos (São Paulo), Brazil
- 7 stops
- Arrival - Itajai, Brazil
1 / 19
8 % off
Duration
7 nights
Date
27 Feb 2027
Ship
MSC Musica
- Departure - Paranaguá, Brazil
- 7 stops
- Arrival - Paranaguá, Brazil
Show all departures (7)
1 / 19
8 % off
Duration
5 nights
Date
9 Mar 2027
Ship
MSC Musica
- Departure - Rio de Janeiro, Brazil
- 5 stops
- Arrival - Itajai, Brazil
1 / 19
8 % off
Duration
7 nights
Date
20 Feb 2027
Ship
MSC Musica
- Departure - Paranaguá, Brazil
- 7 stops
- Arrival - Paranaguá, Brazil
40 of 416 pcs