Central & South America Cruise Dates - 2026 & 2027

Uncover the rich culture, vibrant cities, and dramatic landscapes of Central and South America on a cruise adventure like no other. Plan your unforgettable Central & South America 2026 & 2027 voyages now — book early for the best cabins and exclusive early bird offers. Looking for inspiration? See our Central & South America cruise destination page.

Explore our wide selection of Central & South America cruises below. Use the filters to find the perfect itinerary that matches your travel dates and preferences.

South America
Panama Canal
Galapagos

We found

416 cruises

MSC Musica, South America
1 / 19
MSC Cruises
South America
Duration
1 night
Date
1 Apr 2027
Ship
MSC Musica
  • Departure - Santos (São Paulo), Brazil
  • 2 stops  
  • Arrival - Rio de Janeiro, Brazil
From
£49
Price per person / inside stateroom
MSC Virtuosa, South America
1 / 39
MSC Cruises
South America
Duration
1 night
Date
3 Apr 2027
Ship
MSC Virtuosa
  • Departure - Santos (São Paulo), Brazil
  • 2 stops  
  • Arrival - Rio de Janeiro, Brazil
From
£49
Price per person / inside stateroom
MSC Virtuosa, South America
1 / 39
MSC Cruises
South America
Duration
1 night
Date
1 Dec 2026
Ship
MSC Virtuosa
  • Departure - Rio de Janeiro, Brazil
  • 2 stops  
  • Arrival - Santos (São Paulo), Brazil
From
£59
Price per person / inside stateroom
MSC Musica, South America
1 / 19
MSC Cruises
South America
Duration
1 night
Date
14 Mar 2027
Ship
MSC Musica
  • Departure - Itajai, Brazil
  • 2 stops  
  • Arrival - Santos (São Paulo), Brazil
From
£134
Price per person / inside stateroom
MSC Musica, South America
1 / 19
MSC Cruises
South America
Duration
2 nights
Date
20 Dec 2026
Ship
MSC Musica
  • Departure - Santos (São Paulo), Brazil
  • 3 stops  
  • Arrival - Rio de Janeiro, Brazil
From
£169
Price per person / inside stateroom
Costa Serena, South America
1 / 19
Costa Cruises
South America
Duration
3 nights
Date
8 Apr 2027
Ship
Costa Serena
  • Departure - Rio de Janeiro, Brazil
  • 2 stops  
  • Arrival - Recife, Brazil
From
£199
Price per person / inside stateroom
MSC Musica, South America
1 / 19
MSC Cruises
South America
Duration
1 night
Date
13 Mar 2027
Ship
MSC Musica
  • Departure - Paranaguá, Brazil
  • 2 stops  
  • Arrival - Itajai, Brazil
From
£214
Price per person / balcony stateroom
MSC Musica, South America
1 / 19
MSC Cruises
South America
Duration
2 nights
Date
13 Mar 2027
Ship
MSC Musica
  • Departure - Paranaguá, Brazil
  • 3 stops  
  • Arrival - Santos (São Paulo), Brazil
From
£259
Price per person / balcony stateroom
Costa Diadema, South America
1 / 26
Costa Cruises
South America
Duration
3 nights
Date
20 Nov 2026
Ship
Costa Diadema
  • Departure - Salvador de Bahia, Brazil
  • 3 stops  
  • Arrival - Santos (São Paulo), Brazil
From
£269
Price per person / inside stateroom
MSC Musica, South America
1 / 19
Discount
MSC Cruises
South America
Duration
3 nights
Date
23 Nov 2026
Ship
MSC Musica
  • Departure - Santos (São Paulo), Brazil
  • 3 stops  
  • Arrival - Santos (São Paulo), Brazil
£274
From
£266
Price per person / inside stateroom
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